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10.3390/ijms24043229 200 WaismanA.HauptmannJ.RegenT
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(1) Omega-3 PUFAs (EPA/DHA) as core antidepressant components Deep-sea fish (e.g., salmon, mackerel) contain 23 g/100 g of EPA and DHA, which target two key pathways of depression: Inhibiting microglial activation: by inhibiting the NF-B/MAPK p38 signaling pathway and activating the neuronal BDNF-PI3K/AKT pathway, the process achieves a balance in microglial M1/M2 polarization and provides neuroprotection against neuroinflammation (313)
The exposure of M4 and M5 in the oral group was higher than that of M0 in the terminal phase of the plasma concentration time profile, and ASD was stable in the liver microsome incubation system of rats, but metabolism was relatively rapid during anaerobic incubation of intestinal contents of rats , suggesting that the low bioavailability of ASD might have been attributed to the poor gastrointestinal permeability and extensive pre-absorption degradation rather than to the potent first pass metabolism
Luft References Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD (2009) VADT Investigators
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