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Metformin Because extended-release metformin, compared with the immediate-release presentation, is associated with a lower incidence of gastrointestinal adverse effects, such as nausea, vomiting, dyspepsia, and diarrhea, opting for the extended-release presentation is the first step in preventing the adverse effects related to this medication.9,10 The mechanism of action through which metformin triggers gastrointestinal adverse effects is not known, but there is increasing evidence supporting the idea that the pathophysiologic mechanism is secondary to dysbiosis, given the reports that Intestinibacter spp
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Some studies suggest that L-Carnitine may affect thyroid hormone activity
2.4 Statistical analysis The AE reports were analyzed for signal detection using two-by-two contingency tables (Table 1) and four algorithms: the ROR, the PRR, the BCPNN, and the EBGM (shown in Supplementary Table S2)