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Over-expression of glutathione S -transferase in transgenic rice enhances germination and growth at low temperature

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Evolutionally, mTORC2-AKT-GSK3 axis was identified as a critical signaling hub to promote the longevity of CD4+ T cells by preventing LCMV-induced lipid peroxidation [257]

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Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

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Two main pathways can trigger this process, the intrinsic, also called mitochondrial pathway, when apoptosis is initiated by the internal signals of mitochondrial origin, and the extrinsic when apoptosis is activated by external stimuli [16]

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