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However, if the concentration of a metabolite that is distal to the metabolic reaction is expressed as a ratio to a metabolite that is proximal to the metabolic reaction, that ratio may reveal a change in that pathway that could otherwise go undetected

Both excesses and deficiencies of certain nutrients, as well as exposure to heavy metals, toxins, and endocrine disruptors, can disrupt immune tolerance

6.7.2 Therapeutic strategies Wedge resection and laparoscopic ovarian drilling (LOD) have been successfully used to treat PCOS by normalizing ovulation (229)