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The severity of PEM varies widely, with recovery times ranging from hours to weeks, and it has been shown that in CFS patients who have symptoms of PEM, a physical exercise programme may lead to the worsening of their symptoms (Vink and Vink-Niese, 2020)

It also increases the activity of acyl coenzyme A cholesterol acyltransferase (ACAT), a rate-limiting enzyme in bile acid production

They may also be used to treat certain medical conditions that interfere with the absorption of vitamin B12 from the diet

Patients with any degree of renal impairment should be monitored for dehydration and worsening kidney function if severe gastrointestinal adverse events occur

Providers can legally treat only a fixed number of patients with buprenorphine