Signs You May Be Losing Weight Too Quickly Watch for physical signals that rapid weight loss may be harming your health: persistent fatigue despite adequate sleep, dizziness or lightheadedness, hair thinning or noticeable hair shedding, cold intolerance, brittle nails, or a feeling of muscle weakness
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Thus, in a nutshell, it is possible that the initial DNA damage that predisposes melanocytes to malignant transformation and cytogenetic alterations that later promote actual malignant transformation of the initially transformed melanocytes may be driven by dysregulation in melanin biosynthesis and by the increased cellular content of melanin [10]