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In the CNS, CCL11 has been implicated in age-associated cognitive decline, psychiatric disorders, multiple sclerosis (MS), and Alzheimers disease (AD) (reviewed in: 27 )
J., Andersen, T
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Alternative Names: Tesamorelin (GHRH Analog), CJC-1295 (Modified GRF 1-29), Ipamorelin (Synthetic Pentapeptide) Tesamorelin & CJC-1295 (Mod GRF 1-29) & Ipamorelin Studies and Research Data Potential Pituitary Signaling Pathways Research on Tesamorelin and CJC-1295 suggests that they may bind to GHRH receptors, potentially initiating intracellular signaling cascades involving cyclic adenosine monophosphate (cAMP) and protein kinase pathways
The 12-week Phase 2b trial in 2007 at 1 mg/day did not meet the primary weight-loss endpoint
