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Thus, dehydro-alanine (acrylate) glutathione can irreversibly bind to and inactivate other key enzymes for which glutathione is a substrate or a regulatory cofactor and thus possess a glutathione-docking motif in their tertiary structure

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As the two -CT motifs in IGF1R dimer is covalently linked by multiple disulfide bonds between three cysteine residues C669, C670, and C672, the rigidification and relocation of the -CT induced by binding of one IGF1 leads to the conformational change of the other -CT in the adjacent protomer (Fig

The shelf life of reconstituted peptides can vary, but generally, they are stable for 2-4 weeks when properly stored