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Subsequently, we employed the incorporation of maleimide-liposomes, renowned for their capacity to disrupt the ROS delivery system, to ameliorate the drugs water solubility and pharmacokinetics, thereby enhancing its ROS-disruptive efficacy

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OARSI pathological scoring confirmed higher scores in the OA group compared to the sham group, whereas metformin treatment resulted in a numerically lower OARSI score than that of the OA group, although the difference was not statistically significant (Fig