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Peripheral and central inflammation can both stimulate the KYN pathway and trigger TRP metabolism and subsequent synthesis of various TRYCATs, including the toxic NMDAR activator QUIN, 246 which influences glutamate transmission, has a variety of immunomodulatory effects and has both neurotoxic and neuroprotective effects on the CNS

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Camras C.B., Bito L.Z., Toris C.B