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In a model of cognitive decline associated with diabetes, BBR treatment decreases levels of inflammatory factors such as IL-6, iNOS, and TNF-, increases acetylcholine levels and permeability of the blood-brain barrier, thereby improving cognitive performance in mice (Gupta et al., 2025)

CD8 + T cell isolation and culture Peripheral blood mononuclear cells (PBMCs) were isolated from anonymized healthy blood donors obtained from the National Health Service (NHS) Blood and Transplant (Addenbrookes Hospital) or the Blood Donor Center at Boston Childrens Hospital

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I., Paley, C

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