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If increased homocysteine or methylmalonic acid levels and a normalization of these metabolites in response to replacement therapy are used as diagnostic criteria for vitamin B 12 deficiency, approximately 50 percent of these patients have serum vitamin B 12 levels above 200 pg per mL

B12 serves as a cofactor for enzymes critical for DNA synthesis, red blood cell formation, and nervous system function

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Predrag Sikiric at the University of Zagreb, where the gastric body protection compound was first isolated