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Skin penetration, plasma binding, and copper-pool dynamics complicate dose extrapolation

G6PD deficiency was first discovered by investigating a possible genetic basis for sensitivity to primaquine, and early studies have documented the clinical manifestation of primaquine-induced AHA in G6PD-deficient volunteers who were adults

However, there is still lack of effective clinical treatment for hyperuricaemia

A 2024 study using specialized delivery systems found that copper peptide formulations increased activation of key proteins in this pathway

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