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A mitochondrial DNA sequence variation affecting a subunit of NADPH-ubiquinone reductase (complex 1), a component of the electron transport chain responsible for generating superoxide, has also been associated with schizophrenia patients and with increased superoxide levels in post-mortem brain samples (Marchbanks et al

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The pre-clinical intervention framework centers on removing identified triggers (dietary, environmental, infectious), restoring gut barrier integrity, supporting immune regulation through nutrient optimization (vitamin D, omega-3 fatty acids, glutathione, zinc, selenium), addressing HPA axis dysfunction, and monitoring antibody trends over time

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Biometals 36, 263281