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The origin of these placental insults induced by OS and ER stress is not completely understood, but ischemia/reperfusion and hypoxia-reoxygenation are considered as significant contributors
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J., Balaish, M., Wadaguchi, M., Kong, L
2000;46(8 Pt 2):127783 Accessed May 27, 2018
This means: The same dose stops working as effectively Higher doses may be required (not sustainable) Side effects or inflammatory signals may increase Cellular response plateaus or worsens Strategic cycling allows receptors to reset, restore sensitivity, and respond optimally to the peptide
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