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The sublingual route may be simpler to prepare and administer than nasal spray but has its own challenges, including peptide degradation by salivary enzymes and the difficulty of keeping the solution under the tongue long enough for absorption

In addition, optogenetic enhancement of the E/I ratio in the mouse neocortex provoked deficits in social behaviors relevant to autism 11

[DOI] [PMC free article] [PubMed] [Google Scholar] 241.Mrkl S., Butler M.I., Lackner S

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The key regulatory genes of ferroptosis, such as SLC7A11, GPX4, and voltage-dependent anion-selective channels (VDACs) [1,2,3], can be regulated by a series of deubiquitinases, including ubiquitin-specific protease (USP) 11 [93], USP14 [94], and OTU domain-containing ubiquitin aldehyde-binding protein 1 [95], as well as ubiquitinases such as neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) [96], NEDD4 ligase [17], and so on