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Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene, the direct target of semaglutide), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) describe the terrain the molecule acts on

The INFORM survey, a U.S.-based study of 550 adults using semaglutide for weight management, was presented at the 2025 Annual Meeting of the European Association for the Study of Diabetes in Vienna

Shima Hadidchi MD Family Practice

6 Yet in 2016, data from the SUSTAIN-6 trial comparing semaglutide to placebo over two years showed a possible increased risk of complications of diabetic retinopathy, including vitreous hemorrhage

Higher doses approved specifically for weight management, such as semaglutide 2.4 mg (Wegovy) and liraglutide 3 mg (Saxenda), can achieve more substantial weight reductions of 10-15%