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The defining characteristic is the durable growth arrest, typically enforced by the activation of tumor suppressor pathways involving key cell cycle inhibitors like p16 Ink4a (encoded by CDKN2A ) and p21 Cip1 (encoded by CDKN1A ), often acting via p53 and the retinoblastoma protein (pRB) [50, 51]
doi: 10.1080/13693780701651681 54 NaganawaRIwataNIshikawaKFukudaHFujinoTSuzukiA
We also use it for serious or persistent infections
It circulates through your system, identifying and neutralizing free radicalsunstable molecules that can damage cells if left unchecked
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