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GO analysis on significantly up- or down-regulated transcripts supported the ability of SEMA to counteract stroma development improving anti-tumoral response (Fig

GLP-1 receptor agonists demonstrate proven efficacy with 1.8% HbA1c reduction and 6.1kg weight loss in clinical trials Approved peptide drugs show favourable safety profiles, but unregulated products pose contamination risks, with purity ranging from 1.7% to 100% Regulatory compliance varies significantly: the FDA classifies peptides as drugs, whilst WADA prohibits many peptides in competitive sport

Glibenclamide did not reverse the antinociceptive effect of nicorandil in nociceptive threshold and cumulative scores assessed by von Frey and acetone test in CCI rats, respectively, or block the effect of nicorandil in formalin test

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