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The historical perspective Initial clinical findings that the intestinal epithelium of IBD patients is more permeable to tracer molecules known to permeate through the paracellular space 28, 29, 30, 31 led to the hypothesis that an uncontrolled mucosal barrier may help promote IBD pathogenesis

Pregnant or breastfeeding women: Not enough reliable data to confirm safety better to avoid or have medical supervision

No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

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Connective tissue and fibroblast senescence in skin aging