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Melanocytes are located in the basal layer of the epidermis and synthesize melanin, which plays a key role in photoprotection against UV radiation (224)

Biochim Biophys Acta 1724:108118

Nature 481 , 385388 (2011)

In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited

Cells were spun down at 100 rcf for 3 min and each single microwell contained at least 5000 cells, cultured in E8F medium (without antibiotic) containing 10 M ROCK inhibitor Y-27632 (10 mM stock, Stemcell Technologies, USA #72304)