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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

BPC-157 has extensive animal data for both gastrointestinal and neurological effects but lacks published large-scale human clinical trials for depression specifically

After electromagnetic fields affect the membrane potential of nerve cells, DSIP may participate in regulating the opening and closing of voltage-gated calcium or sodium channels, affecting the conduction of nerve impulses and subsequently affecting physiological processes such as sleep regulation

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