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In addition, GLP-1R can be continuously activated to activate cAMP and P38 (94) and inhibit the conduction of the AKT and ERK1/2 signaling pathways (14, 16), ultimately inhibiting the proliferation of transplanted tumors in vivo and inducing the apoptosis of human pancreatic cancer cells in vitro ( 14)
doi: 10.1038/35025220 86 LorussoGRueggC
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However, caution is necessary when considering senotherapeutics for endometriosis, given the physiological role of transient senescence in endometrial receptivity and decidualization [16]
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