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Bacteria deploy specialized mechanisms to deal with the oxidative stress [58] which include enzymes like SOD, thioredoxin reductase system, glutathione-glutaredoxin system and NADH oxidase/ NADH peroxidase system

Chen R, Kang R, Tang D

However, the copper complex provides some stability against enzymatic breakdown

[DOI] [PMC free article] [PubMed] [Google Scholar] 288.Fedorak RN, Feagan BG, Hotte N, Leddin D, Dieleman LA, Petrunia DM, et al

Both modifications sit in the region that IGF binding proteins recognise, and the functional consequence is a large loss of IGFBP affinity while type 1 IGF receptor binding is largely preserved