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The first six amino acids of native GLP-1 are absent, and two key substitutions are introduced: at position 8, alanine is replaced by 2-aminoisobutyric acid (Aib) to prevent degradation by dipeptidyl peptidase-4 (DPP-4), and at position 34, lysine is replaced by arginine to improve stability

Like any medication, Ozempic may have side effects, and individuals need to discuss its use and potential risks with their healthcare provider

Similarly, effects on menstrual cycles and energy levels are related to the pharmacological action of the drug, not its appearance

GI, gastrointestinal

SUSTAIN-6 was pivotal, revealing a 26% reduction in adverse heart outcomes