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The rationale is based on the peripheral manifestation of neurodegenerative pathology, specifically, the accumulation of misfolded proteins such as phosphorylated -synuclein (P-SYN) in small nerve fibers of the skin

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ACS Chemical Biology, 8 (9), 19121917

So I had the awful reaction from the beginning of February basically until end of May, which is when I went to the dermatologist

Colchicine, Neomycin, Aminosalicylic Acid, H2-blockers (e.g., Ranitidine), and Proton Pump Inhibitors (PPIs, e.g., Omeprazole): These oral medications can all interfere with the intestinal absorption of dietary B12, making the need for injectable B12 more pronounced