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Nat Med 30 , 20372048 (2024)

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Although the meta-regression did not significantly reduce the overall heterogeneity, it confirms that the high heterogeneity is driven by a combination of multiple factors rather than a single dominant study feature

The dark side theory of addiction contends that impulsivity, compulsivity and negative urgency are derived from stress experienced during withdrawal or negative affect stage, even several months into abstinence