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Your carefully planned fueling strategy goes out the window when your gut can't process energy quickly enough, leading to bonking, underperformance, and general misery

Upon binding, it activates the Gs/adenylyl cyclase/cAMP/PKA cascade, leading to glucose-dependent insulin secretion from pancreatic beta cells

Think of NF-kB sort of like a firefighter, it sits inside cells, waiting for a signal that something is wrong (like an injury, an infection, or stress) only then does it activate and tell the cell how to defend itself

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