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It was proposed that these transporters play a key role maintaining the glutamate gradient between brain cells and extracellular fluid, since they are the most important players because they catalyze Glu efflux from the brain

350,351 In addition to mediating the adaptive and innate immune responses, MHCI molecules contribute to controlling axonal and synaptic growth and participate in the regulation of synaptic plasticity and synaptic homeostasis in the presynaptic and postsynaptic regions associated with glutamate

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Supports ATP production and balances oxidative stress*