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Despite hopes raised by earlier observational studies and biomarker shifts, The Lancet trials found that oral semaglutide did not meaningfully slow clinical progression in early Alzheimers disease over two years

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However, after cessation of IMP at 6 months, those in the liraglutide arm experienced both a statistically significant rise in HbA1c and weight that was not seen in the placebo arm

It has been shown to reduce inflammation by modulating immune responses and inhibiting the release of inflammatory mediators