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The most common issues are gastrointestinal, such as nausea (reported by ~44% of users), diarrhea , and vomiting

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While this supports weight loss, it can also reduce available energy, particularly if the body is not yet fully adjusted to the lower intake

Specifically, we consider contributions of both central and peripheral GLP-1 and propose an integrated model of short-term and long-term control of energy balance

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