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Multidisciplinary Digital Publishing Inst (Mdpi) (2025) 30:774

Overall, the results strongly indicate that a short-term HF diet induces detrimental effects on memory, exploration, and anxiety in zebrafish, and MT-II treatment effectively reverses these negative neurobehavioral changes [2]

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In addition, oral and localized administration routes differ significantly in tissue exposure, pharmacokinetics/pharmacodynamics, and safety marginsyet comprehensive studies on dosage optimization, tissue targeting, and half-life remain lacking