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Dual agonist medications such as tirzepatide may lead to even more substantial reductions once therapeutic dosing is reached

Clinical trials on the effects of N-acetylcysteine (NAC) supplementation on ovulation and sex hormones profile in women with PCOS have been controversial

Importantly, semaglutidetreated patients experienced sustained weight loss (mean ~10.2% vs 1.5% at 208 weeks) and improvements in waist circumference and waisttoheight ratio, anthropometric changes that track with cardiometabolic risk reduction

As a result, patients are frustrated as pharmacies are unable to keep up with this mismatch