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Published comparative studies demonstrate that ipamorelin produces GH release without significant elevation of ACTH, cortisol, or prolactin, even at doses exceeding 200-fold the GH-releasing ED50 in animal studies

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Furthermore, it was recently reported that use of GLP-1RAs for more than 6 months increased the risk of neovascular age-related macular degeneration (nAMD) by about twofold, although the association between a gastric inhibitory polypeptide (GIP)/GLP-1 receptor dual agonist (GIP/GLP-1RA) and nAMD is not clearly established

doi: 10.1038/bjc.2017.317 140 SuKGuoLMaWWangJXieYRaoMet al