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rAAV9-PRMT1 was developed by cloning the target gene PRMT1 into an AAV serotype 9 vector containing the kidney-specific promoter KSPC (GPAAV-KSP0.3k-Mouse_Prmt1-T2A-eGFP-WPRE) (Fig

doi: 10.1038/s41598-022-23834-1 26 AhdiHSWichelmannTAPandravadaSEhrenpreisED

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The simultaneous increase in NADP and decrease in NADPH act additively to increase G6PD activity by increasing the substrate drive on the reaction rate and decreasing product inhibition