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The conclusion of this research stated, that the addition of PIC to Ferrous Fumarate surprisingly allows the same concentration of Ferrous Fumarate to be better tolerated than the Ferrous Fumarate alone

NeuroReport 7:18331836 Raps SP, Lai JC, Hertz L, Cooper AJ (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

The Nitric Oxide Pathway L-Citrulline works through the following pathway: [4] When consumed, L-citrulline bypasses the liver's first-pass metabolism and enters the bloodstream efficiently