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doi: 10.1024/0300-9831.79.3.131.

Without a transporter, they remain blocked in the cytoplasm and cannot be burned to produce energy

Betaine serves as an osmolyte and methyl group donor, playing a role in the re-methylation of homocysteine into methionine, a precursor of S-adenosylmethionine (SAM), essential for numerous methylation reactions, including DNA epigenetics ( De novo PC synthesis begins with the phosphorylation of choline by the enzyme choline kinase (ChoK) into phosphocholine ( Figure 2 )

thus requiring higher levels of dietary proteins 10