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Leung and Kyung, 2024)

Tsai notes that many physicians will need to be educated on the Bridge program

When NNMT is too active, it consumes our precious supply of NAD+ (nicotinamide adenine dinucleotide), a coenzyme that is absolutely essential for cellular energy production and DNA repair

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To gain further insight, a non-compartmental PK analysis was performed using gPKPDSim 74 , which revealed a 3.8-fold slower clearance rate (CL) and a 2.4-fold longer mean residence time (MRT) of QMP compared with WT albumin (Supplementary Table 4)