134 In addition, a clinically significant DDI was reported in a Phase I study of ALRN-6924, an analog of ATSP-7041 and an inhibitor of OATP1B3
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This mechanism can be particularly advantageous for patients with hypothyroidism, who often struggle with weight gain and difficulty losing weight due to their slowed metabolism
When discontinued, patients commonly experience weight regain as the medication's effects fadeclinical trials show approximately 14% weight regain over one year after stopping treatment
Researchers observed that weight loss with semaglutide ranged from 9.6 to 17.1% in participants without gastrointestinal AEs and from 11.4 to 17.7% in those with gastrointestinal AEs, suggesting gastrointestinal AEs appeared to contribute little to the weight-loss benefit of semaglutide, which were consistent with previous studies that the weight-loss effects of semaglutide in patients with obesity and/or T2DM indicated little contribution of gastrointestinal AEs (26, 36, 37)
