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What can be said is that they sit on very different evidence tiers: tesamorelin is FDA-approved with multiple Phase 3 randomized trials for reducing visceral fat in HIV-associated lipodystrophy, while CJC-1295 is unapproved, with only two small early-phase human studies measuring GH and IGF-1 surrogates

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Glucagon receptor activity can increase energy expenditure, push the liver toward fat oxidation, and raise lipid turnover

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