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Muscle loss on a protein-deficient calorie deficit typically becomes measurable within 24 weeks, though you may not notice it subjectively until 68 weeks when strength loss becomes apparent during exercise

The published case literature supports this, showing that most patients who continued tirzepatide through mild to moderate injection site reactions experienced gradual improvement without needing to discontinue

It adds that most telogen effluvium then resolves within three to six months once nutritional status and metabolic stress improve

Adding the second receptor improved weight loss from roughly 15% to 22.5% in clinical trials (Jastreboff et al., NEJM 2022)

[13] [14] Studies in general weight management populations have shown that higher protein intakes, including whey protein supplementation, can support better body composition outcomes during weight loss interventions compared to lower protein intakes