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Matrix metalloproteinases (MMPs) involved in vascular matrix remodeling, specifically, MMP-2 and MMP-9 are upregulated after tPA administration in focal cerebral ischemia (Wang and Chen, 2020)

Additionally, inflammation might compromise the overall health of the gut lining, which could indirectly affect histamine regulation

Chloroquine (CQ), which is commonly employed in the management of malaria and inflammatory conditions, has demonstrated potential as a novel anticancer agent through its ability to inhibit autophagy and induce apoptosis 10

These medications, initially developed for managing type 2 diabetes, are now widely recognized for their ability to suppress appetite, regulate blood sugar, and promote significant weight loss

There is strong evidence for the latter