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PUFA-PLs are susceptible to oxidation induced by free radicals mediated by lipoxygenases (ALOXs), which eventually lead to the destruction of the lipid bilayer and affect the membrane function, thus triggering ferroptosis [19, 20]

However, A plaques in these spaces can lead to reduced expression of AQP4 at the astrocytic end-feet, adversely affecting A efflux with the ISF and exacerbating intraparenchymal A deposition [58, 173, 174]

PubMed Central PMCID: PMC9821052

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00:23:07 Craig Williams We are dealing more with what happens when a patient loses 80 or 100 pounds and their A1C is truly normalized and theyre still on these medications that dont cause hypoglycemia