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In macrophage models, -KG promotes JMJD3-mediated H3K27me3 demethylation, thereby favoring the expression of M2-related genes, whereas succinate accumulation can inhibit demethylase activity and sustain a pro-inflammatory transcriptional state ( It should be noted that most current evidence regarding amino acid-mediated regulation of macrophage polarization is derived from in vitro cell models or animal experiments, whereas systematic validation in human clinical samples remains relatively limited

Rapid Commun Mass Spectrom 31, 1290-1296 (2017)

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The phenomenon has prompted aesthetic providers to adapt their practices as patients increasingly seek GLP-1 agonist treatments

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