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mTOR signaling in skeletal development and disease

When these signals become dysregulated, the body may hold onto fat even when someone is actively trying to lose weight

The best treatment is not just what works on paper, it is what a patient can realistically stick with over time

On the other hand, a primary defect in energy metabolism (mitochondrial disease, genetic component being in a gene involved in energy metabolism) will result in delayed homeostasis of the ion gradient in active neurons and their associated glia due to under function of the ATP-dependent cation pumps

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