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developed a type 2 diabetes simulator with 100 virtual subjects, incorporating PK/PD modules for metformin and liraglutide that recapitulated clinical meal tolerance test outcomes (Visentin et al., 2022, DOI)

The ligand-activated transcription factor NOTCH1 represents one of the most recurrently mutated genes, with ~10% of patients carrying the mutation at diagnosis [8,9,10,11]

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