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Immediate medical attention is warranted if missed periods are accompanied by concerning symptoms such as severe abdominal pain, heavy bleeding, abnormal vaginal discharge, signs of pregnancy, symptoms of thyroid dysfunction (significant fatigue, cold intolerance, hair loss), or signs of hyperprolactinaemia (galactorrhoea, visual disturbances, headaches)

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Trial STEP 2 (Davies et al., Lancet 2021) Design Phase 3 / 68 weeks Population 1,210 adults with T2D and overweight or obesity Key result -9.6% body weight (2.4 mg) vs -3.4% placebo