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It is worth mentioning that most pathological changes caused by NSAIDs occur in the lower part of the digestive tract

Insomnia can have many causes, including anxiety, depression, trauma, chronic pain, sleep apnea, restless legs syndrome, circadian rhythm disruption, medications, alcohol use, hormone changes, and stress

Research suggests they may enhance tissue repair in muscles, ligaments, and tendons, while also improving mobility and resilience

Formulations with cyclodextrins help avoid these problems by providing gradual and localized drug release [197]

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