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The three receptors it targets are: GLP-1 receptors : Help control appetite and slow digestion GIP receptors : Support insulin function and glucose regulation Glucagon receptors : Promote energy expenditure and fat burning This triple-action approach sets Retatrutide apart from current FDA-approved medications, such as semaglutide (found in Ozempic and Wegovy), which only target GLP-1 receptors, and tirzepatide (Mounjaro and Zepbound), which targets both GLP-1 and GIP receptors

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Others, relying on more conservative default USP guidelines, might assign BUDs as short as 14 days