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Figure 5 illustrates the antidiabetic mechanism of polyphenols in the human body, showing deconjugation in the gastrointestinal tract, absorption, hepatic portal circulation, reconjugation in the liver, biliary excretion, renal excretion, and microbial deconjugation in the colon, ultimately leading to fecal excretion

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The most studied histone -modified mechanisms of DCM include heart failure, arrythmias, coronary artery disease, hypertension, endothelial hyperplasia and smooth muscle cell migration (129)